Immunotrafficking Lab

Physics and Astronomy, University of Manitoba

Book chapters

Featured as journal covers

Integrative Biology, 2017, 9(11)

Micromachines, 2017, 8(11)

 

 

 

Integrative Biology, 2017, 9(4)

Lab on a Chip, 2016, 16(6)

 

2019

[98] J. Hipolito, H. Peretz-Soroka, M.L. Zhang, K. Yang, S. Karimi-Abdolrezaee, F. Lin and S.K.P. Kung, “A New Microfluidic Platform for Studying Natural Killer Cell and Dendritic Cell Interactions”, Micromachines, 2019, 10, 851.

[97]
Q. Jiang, J.D. Wu, K. Yao, Y.L. Yin, M.M. Gong, C.B. Yang and F. Lin, “A paper-based microfluidic device (DON-Chip) for rapid and low-cost deoxynivalenol quantification in food, feed and feed ingredients”, ACS Sensors, 2019, 4, 11, 3072-3079.

[96]
B. Dai, S.J. Chen, W. Li, L.L. Zheng, X.D. Han, Y.F. Fu, J.D. Wu, F. Lin, D.W. Zhang and S.L. Zhuang, “Fully-functional semi-automated microfluidic immunoassay platform for quantitation of multiple samples”, Sensors and Actuators B: Chemical,
300 (2019) 127017.

[95]
R.Q. Yang, Q.R. Hui, Q. Jiang, S.X. Liu, H. Zhang, J.D. Wu, F. Lin, K. O and C.B. Yang, “Effect of Manitoba-grown red-osier dogwood extracts on recovering Caco-2 cells from H2O2-induced oxidative damage”, Antioxidants, 2019,
8, 250.


[94] X.O. Ren, A. Alamri, J. Hipolito, F. Lin and S.K.P. Kung, “Applications of microfluidic devices in advancing NK-cell migration studies”, Methods in Enzymology, 2019, https://doi.org/10.1016/bs.mie.2019.05.052.


[93]
J. Li, R. Nickel, J.D. Wu, F. Lin, J. van Lierop and S. Liu, "A new tool to attack biofilms: Driving magnetic nanoparticles to disrupt the matrix", Nanoscale, 2019, 11(14):6905-6915.


[92]
X.O. Ren, J.D. Wu, D. Levin, S. Santos, R. Lobato de Faria, M. Zhang, and F. Lin, “Sputum from chronic obstructive pulmonary disease patients inhibits T cell migration in a microfluidic device
”, Ann NY Acad Sci, 2019, 1445(1):52-61.

[91] K. Yang, J.D. Wu, S. Santos, Y. Liu, L. Zhu and F. Lin, “Recent development of portable imaging platforms for cell-based assays”, Biosensors and Bioelectronics, 2019, 124-125, 150-160.

[90] Z. Rovei Miab, F. Lin and J. Anderson, “Emerging development of microfluidic-based approaches to improve studies of muscle cell migration”, Tissue Engineering Part B Rev. 2019, 25(1):30-45.

 

2018


[89] J.D. Wu, A. Kumar-Kanojia, S. Hombach-Klonisch, T. Klonisch and F. Lin, "A radial microfluidic platform for higher throughput chemotaxis studies with individual gradient control", Lab on a Chip, 2018, 18, 3855 - 3864.

[88] J.D. Wu, D. Tomsa, M. Zhang, P. Komenda, N. Tangri, C. Rigatto and F. Lin, "A Passive Mixing Microfluidic Urinary Albumin Chip (UAL-Chip) for Chronic Kidney Disease Assessment", ACS Sensors, 2018, 3(10):2191-2197.

[87]
J.D. Wu, M.L. Dong, C. Rigatto, Y. Liu and F. Lin, “Lab-on-chip technology for chronic disease diagnosis”, npj Digital Medicine, 2018, 1:7.


[86]
J. Hipolito, H. Peretz-Soroka, A.M. Torres, E. Booy, K. Yang, M. Gupta, M. Meier, S. McKenna, M. Koch, S. Santos, J. Stetefeld and F. Lin, “Microfluidic Devices for Studying the Effect of Netrin-1 on Neutrophil and Breast Cancer Cell Migration”, Advanced Biosystems, 2018, 2(4), 1700178.

[85]
A.Y. Ali, X. Wu , N. Eissa, J.E. Ghia, T. Murooka, V. Banerji, J.B. Johnston, F. Lin, S.B. Gibson and A.J. Marshall, “Distinct roles for the phosphoinositide 3-kinase gamma and delta isoforms in malignant B cell migration”, Leukemia, 2018, 32, 1958–1969.


[84] K. Yang, J.D. Wu, H. Peretz-Soroka, L. Zhu, Z.G. Li, Y.S. Sang, J. Hipolito, M. Zhang, S. Santos, C. Hillier, R. Lobato de Faria, Y. Liu and F. Lin, “Mkit: A Cell Migration Assay Based on Microfluidic Device and Smartphone”, Biosensors and Bioelectronics, 2018, 99:259-267.

 

2017

[83] J.D. Wu, M.L. Dong, S. Santos, C. Rigatto, Y. Liu and F. Lin, “Lab-on-chip systems for detection of cardiovascular disease and cancer biomarkers”, Special Issue of "Sensors for Health Monitoring and Disease Diagnosis", Sensors, 2017, 17(12), 2934.

[82] K. Yang, J.D. Wu, L. Zhu, Y. Liu and F. Lin, “A triple-unit microfluidic device (D3-chip) for cell migration research”, Protocol Exchange, 2017, DOI: 10.1038/protex.2017.133. http://dx.doi.org/10.1038/protex.2017.133

[81]
X.O. Ren, D. Levin and F. Lin, “Cell migration research based on organ-on-chip related approaches”, Special Issue of “Integrated Microfluidics for Chemical Synthesis and Analysis”, Micromachines, 2017, 8(11), 324. Featured as the cover image.

[80]
H. Peretz-Soroka, R. Tirosh, J. Hipolito, E. Huebner, M. Alexander, J. Fiege, F. Lin, “A bioenergetic mechanism for amoeboid-like cell motility profiles tested in a microfluidic electrotaxis assay”, Integrative Biology, 2017, 9, 844 - 856. Featured as the front cover image.

[79]
E.P. Booy, E. KS McRae, A. Koul, F. Lin and S.A. McKenna, “The long non-coding RNA BC200 (BCYRN1) is critical for breast cancer cell survival and proliferation”, Molecular Cancer, 2017, 16:109.

[78]
Y. Zhang, G.Q. Xu, R.M Lee, Z.J. Zhu, J.D. Wu, S. Liao, G. Zhang, Y.H. Sun, A. Mogilner, W. Losert, T.R. Pan, F. Lin, Z.P. Xu, M. Zhao, “Collective Cell Migration has Distinct Directionality and Speed Dynamics”, Cellular and Molecular Life Sciences, 2017, 74(20), 3841-3850.

[77]
D.X. Xie, “The effects of activin A on the migration of human breast cancer MDA-MB-231 cells and neutrophils”, M.Sc. thesis, Jilin University, 2017. Best thesis award.

[76]
K. Yang, “Development of novel microfluidic device for cell migration and chemotaxis research”, Ph.D. thesis, Chinese Academy of Sciences, 2017.


[75] S. Wong, “Assessing the dose-dependent chemotaxis of adipose-derived stem cells to epidermal growth factor using a new microfluidic device”, Honours thesis, University of Manitoba, 2017.


[74] D.X. Xie, Z.H. Liu, J.D. Wu, W.F. Feng, K. Yang, J.X. Deng, G.H. Tian, S. Santos, X.L. Cui and F. Lin, "The effects of activin A on the migration of human breast cancer cells and neutrophils and their migratory interaction", Experimental Cell Research, 2017, 357, 107–115.


[73]
K. Yang, H. Peretz-Soroka, J.D. Wu, L. Zhu, X.L. Cui, M. Zhang, C. Rigatto, Y. Liu and F. Lin, "Fibroblast growth factor 23 weakens chemotaxis of human blood neutrophils in microfluidic devices", Scientific Reports, 2017, 7: 3100, DOI: 10.1038/s41598-017-03210-0.


[72]
M.L. Dong, J.D. Wu, Z.M. Ma, H. Peretz-Soroka, M. Zhang, P. Komenda, N. Tangri, Y. Liu, C. Rigatto and F. Lin, "Rapid and low-cost CRP measurement by integrating a paper-based microfluidic immunoassay with smartphone (CRP-Chip)", Special issue of "State-of-the-Art Sensors Technology in Canada 2017", Sensors, 2017, 17(4), 684.

[71]
K. Yang, J.D. Wu, G.Q. Xu, D.X. Xie, H. Peretz-Soroka, S. Santos, M. Alexander, L. Zhu, M. Zhang, Y. Liu and F. Lin, “A dual-docking microfluidic cell migration assay (D2-Chip) for testing neutrophil chemotaxis and the memory effect", Integrative Biology, 2017, 9, 303 - 312. Featured as the back cover image.

[70] K. Yang, J.D. Wu, L. Zhu, Y. Liu, M. Zhang and F. Lin, “An all-on-chip method for rapid neutrophil chemotaxis analysis directly from a drop of blood”, J. Vis. Exp., (124), e55615, doi:10.3791/55615 (2017). http://www.jove.com/video/55615


[69]
G.Q. Xu, “Mathematical Modeling and Simulation of Collective Cell Migration in Wound Healing and Electrotaxis Experiments”, M.Sc. thesis, University of Winnipeg, 2017.

 

[68] H. Movassagh, A. Saati, S. Nandagopal, A. Mohammed, N. Tatari, L.Y. Shan, J.S. Duke-Cohan, K.R. Fowke, F. Lin, and A.S. Gounni, “Chemorepellent Semaphorin 3E Negatively Regulates Neutrophil Migration in vitro and in vivo”, Journal of Immunology, 2017, 198(3):1023-1033

 

2016


[67]
S.K.P. Kung and F. Lin., “Advances in the Studies of NK Cell Migration Using Microfluidic Devices”, J Cell Signal, 2016, 1:120.

[66]
J.D. Wu, C. Hillier, P. Komenda, R. Lobato de Faria, S. Santos, D. Levin, M. Zhang and F. Lin, “An all-on-chip method for testing neutrophil chemotaxis induced by fMLP and COPD patient’s sputum”, Technology, 2016, 4(2), 104-9. [Press release]

[65]
J.D. Wu, “Development of microfluidics-based neutrophil migration analysis systems for research and clinical applications”, Ph.D. thesis, University of Manitoba, 2016, [link]. Nomination for the Governor General’s Gold Medal.

[64]
S. Nandagopal, F. Lin and S.K.P. Kung, Chapter 7, "Microfluidic-based live-cell analysis of NK cell migration in vitro", Srinivas S. Somanchi (ed.), Natural Killer Cells: Methods and Protocols, Methods in Molecular Biology, vol. 1441, DOI 10.1007/978-1-4939-3684-7_7, Springer, 2016

[63]
K. Yang, H. Peretz-Soroka, Y. Liu and F. Lin, “Novel Developments of Mobile Sensing Based on the Integration of Microfluidic Devices and Smartphone”, Lab on a Chip, 2016, 16, 943-958. Featured as the back cover image; Top 25 most downloaded articles published in the journal in 2016.

[62] H.Z. Li, X. Wu, S. Hou, E. Noha, K.J. Makondo, Q.J. Du, J.A. Wilkins, J.B. Johnston, S.B. Gibson, F. Lin, and A.J. Marshall, “Phosphatidylinositol-3,4-biphosphateand and its binding protein lamellipodin regulate chemotaxis of malignant B lymphocytes”, Journal of Immunology, 2016, 196(2):586-95.

 

[61] J.D. Wu and F. Lin, Chapter 7, “Micro-engineered tools for studying cell migration in electric fields”, for the book ‘Integrative Mechanobiology: Micro and Nano Techniques in Cell Mechanobiology’, Y. Sun, D.H. Kim, and C. Simmons (Eds.), Cambridge University Press, Jan, 2016.

 

2015


[60]
I. Halilovic, J.D. Wu, M. Alexander, F. Lin, “Neutrophil Migration under Spatially-Varying Chemoattractant Gradient Profiles”, Biomedical Microdevices, 2015, Jun;17(3):9963.


[59] J.D. Wu, C. Hillier, P. Komenda, R. Lobato de Faria, D. Levin, M. Zhang and F. Lin, “A microfluidic platform for evaluating neutrophil chemotaxis induced by sputum from COPD patients”, PLoS ONE, 2015 May 11;10(5):e0126523.


[58]
Xun Wu, Jiandong Wu, Hongzhao Li, Daniel F. Legler, Aaron J. Marshall, Francis Lin, “Analysis of CCR7 mediated T cell transfectant migration using a microfluidic gradient generator”, Journal of Immunological Methods, 419 (2015) 9–17.

 

[57] C. Chi, B. Xiang, J.X. Deng, H.Y. Lin, H.Y. Liu, K. Natarajan, F. Lin, D.H. Freed, R.C. Arora, G.H. Tian, “Adipose-Derived Stem Cells from both Visceral and Subcutaneous Fat Deposits Significantly Improve Contractile Function of Infarcted Rat Hearts”, Cell Transplantation, 2015, 24(11):2337-51.

[56]
K. Natarajan, C. Tian, B. Xiang, C. Chi, J.X. Deng, R.D. Zhang, D.H. Freed, R.C. Arora, G.H. Tian, F. Lin, “Selection of chemotactic adipose-derived stem cells using a microfluidic gradient generator”, RSC Advances, 2015, 5, 6332-6339.

 

2014

 

[55] K. Natarajan, “A microfluidic method for selecting chemotactic stem cells”, M.Sc. thesis, University of Manitoba, 2014, [link].

[54]
X. Wu, “Quantitative cell migration analysis of CCR7-mediated lymphocytes migration using a microfluidic device”, M.Sc. thesis, University of Manitoba, 2014, [link].


[53] J.D. Wu, L.P. Ouyang, M. Zhang, S. Liao, C. Hillier, P. Komenda, R.L. de Faria and F. Lin, “Assessing neutrophil chemotaxis in COPD using a compact microfluidic system”, The 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’14), Chicago, U.S.A., August 26-30, 2014.

[52]
S. Mahmood, S. Nandagopal, I. Sow, F. Lin and S.K.P. Kung, “Microfluidic-based, live-cell analysis allows assessment of NK-cell migration in response to cross-talk with dendritic cells”, European Journal of Immunology, 2014, 44(9):2737-48.
Featured in the "In this issue" section.

[51]
J.D. Wu, L.P. Ouyang, N. Wadhawana, J. Li, M. Zhang, S. Liao, D. Levin and F. Lin, "A compact microfluidic system for cell migration studies", Biomedical Microdevices, 2014, 16(4): 521-528.

[50] J.D. Wu and F. Lin, “Recent Developments in Electrotaxis Assays". Advances in Wound Care, 2014, 3(2):149-155.

[49] S. Nandagopal, “Microfluidics-assisted investigation of T-lymphocyte Migration in lymph node relevant chemokine gradients”, Ph.D. thesis, University of Manitoba, 2014, [link].


2013

 

[48] L.P. Ouyang, “Investigation of Cell Tracking under Microfluidic Device", M.Sc. thesis, University of Winnipeg, 2013.


[47] L.P. Ouyang, J.D. Wu, M. Zhang, F. Lin and S. Liao, “Cell Segmentation and Tracking in Microfluidic Platform". Engineering, 2013, 5, 226-232.

 

[46] J.D. Wu, X. Wu and F. Lin, “Recent Developments in Microfluidics-Based Chemotaxis Studies". Lab on Chip (Canada Theme Issue). 2013, 13(13):2484-99. Most read article for Jun. 2013.

 

[45] D. Wu, X.L. Ma and F. Lin, "DC Electric Fields Direct Breast Cancer Cell Migration, Induce EGFR Polarization and Increase the Intracellular Level of Calcium Ion". Cell Biochemistry and Biophysics, 2013, 67 (3):1115-1125.

 

[44] D. Wu, A.G. Joyee, S. Nandagopal, M. Lopez, X.L. Ma, J. Berry and F. Lin, "Effects of C. difficile toxin A and B on human T lymphocyte migration". Toxins, 2013, 5 (5), 926-938.

[43] Z.M. Li, .Z.H. Bai, D.L. Wang, W.J. Zhang, M. Zhang, F. Lin, L.P. Gao, B.D. Hui and H.X. Zhang, “Cultivable bacterial diversity and amylase production in three typical Daqus of Chinese spirits", International Journal of Food Science and Technology, 2013, 49 (3), 776-786.

 

[42] Li HZ, Hou S, Wu X, Nandagopal S, F. Lin, Kung S and Marshall A, “The tandem PH domain-containing protein 2 (TAPP2) regulates chemokine-induced cytoskeletal reorganization and malignant B cell migration”, PLoS ONE, 2013, 8(2):e57809.

 

2012

 

[41] N. Wadhawan, H. Kalkat (co-first author), K. Natarajan, X.L. Ma, S. Gajjeraman, S. Nandagopal, N. Hao, J. Li, M. Zhang, J.X. Deng, B. Xiang, S. Mzengeza, D. Freed, R. Arora, G.H. Tian and F. Lin, "Growth and Positioning of Adipose-Derived Stem Cells in Microfluidic Devices". Lab on a Chip, 2012, 12 (22), 4829 - 4834.

[40] J. Li, F. Lin, L.D. Li, J. Li and S. Liu, "Surface-engineering of poly(ethylene terephthalate) (PET) for durable haemocompatibility via a surface interpenetrating network technique", Macromolecular Chemistry and Physics, 2012, 213(20), 2120-2129.

[39] J.D. Wu, X. Wu, F. Lin,A stacked microfluidic device for improving experiment throughput, Chips and Tips, May 31, 2012.

[38] L. Zhu, L. Li, D. An, M. Wang, L. Zhang, Y.K. Wang, Z. Li, Y. Liu, G. Zhang, F. Lin, “An Integrated Microfluidic Real-Time PCR System for Pathogen Detection”, TechConnect World 2012, Santa Clara, California, June 18-21, 2012.

[37] N. Wadhawan, H. Kalkat, X. Ma, S. Gajjeraman, S. Nandagopal, N. Hao, J. Deng, B. Xiang, M. Zhang, G. Tian, F. Lin, “Microfluidic Control of Adipose-Derived Stem Cell Growth and Positioning”, TechConnect World 2012, Santa Clara, California, June 18-21, 2012.

[36] Z. Li , Z. Bai, B. Zhang, B. Li, B. Jin, M. Zhang, F. Lin, H. Zhang. “Purification and Characterization of Alkaline Pectin Lyase from a Newly Isolated Bacillus clausii and Its Application in Elicitation of Plant Disease Resistance”, Appl Biochem Biotechnol, 2012, 167(8):2241-56.

[35] J. Li, L. Zhu, M. Zhang and F. Lin, "Microfluidic Device for Studying Cell Migration in Single or Co-Existing Chemical Gradients and Electric Fields", Biomicrofluidics, 2012, 6, 024121.
Top 20 most read article forJun.-Sept. 2012; Top 20 most cited article for 2012-2013.

[34] L. Li, R. Hartley, B. Reiss, Y.H. Sun, J. Pu, D. Wu, F. Lin, T. Hoang, S. Yamada, J.X. Jiang, M. Zhao, "E-cadherin plays an essential role in collective directional migration of large epithelial sheets", Cellular and Molecular Life Sciences, 2012, 69(16):2779-89.

 

2011


[33] J. Li, “Investigation of T Cell Chemotaxis and Electrotaxis Using Microfluidic Devices”, M.Sc. thesis, University of Manitoba, 2011, [link].

[32] D. Wu and F. Lin, "A Receptor Electromigration-Based Model for Cellular Electrotactic Sensing and Migration", Biochem Biophys Res Commun, 2011, 411, 695-701.

[31] D. Wu and F. Lin, "Cell Migration", Chapter 63, Comprehensive Biotechnology, 2nd edition, Vol. 1, 539-546, Elsevier, 2011.

[30] J. Li and F. Lin, "Microfluidic Devices for Studying Chemotaxis and Electrotaxis", Trends in Cell Biology, 2011, Vol. 21, 489-497.
Most downloaded article for Jul.-Sept. 2011.

[29] D. Wu and F. Lin, "Modeling Cell Gradient Sensing and Migration in Competing Chemoattractant Gradients", PLoS ONE, 2011, 6(4): e18805.

[28] F. Lin and C. Pullar, "Inflammatory Cell Electrotaxis", Chapter 8, The Physiology of Bioelectricity in Development, Tissue Regeneration and Cancer, CRC Press, 2011.

[27] S. Neethirajan I. Kobayashi, M. Nakajima D. Wu, S. Nandagopal and F. Lin, "Microfluidics for Food, Agriculture and Biosystems Industries”, Lab on a Chip, 2011, 11 (9), 1574 - 1586.

[26] S. Nandagopal, D. Wu (co-first author) and F. Lin, "Combinatorial Guidance by CCR7 Ligands for T Lymphocyte Migration in Co-Existing Chemokine Fields", PLoS ONE, 2011, 6(3): e18183.
Top 25% most cited paper in PLoS ONE.

[25] J. Li, S. Nandagopal, D. Wu, S.F. Romanuik, K. Paul, D.J. Thomson and F. Lin, "Activated T Lymphocytes Migrate Toward the Cathode of DC Electric Fields in Microfluidic Devices", Lab on a Chip, 2011, 11(7), 1298 -1304.

2010


[24] G.A. Ferrier, M. Nikolic-Jaric,S. Rzeszowski, T. Cabel, S. Nandagopal, F. Lin, M. Butler, G.E. Bridges, D.J. Thomson and M.R. Freeman, "DIELECTROPHORETIC PRESSING OF BIOLOGICAL CELLS INTO CONTACT WITH SURFACES: A MECHANISM FOR BIOPHYSICAL FLOW CYTOMETRY", The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Groningen, Netherlands, 3-7, October, 2010.

[23] M Nikolic-Jaric, G.A. Ferrier, S. Rzeszowski, T. Cabel, S. Nandagopal, F Lin, G.E.. Bridges, D.J. Thomson and M.R. Freeman, "UNCERTAINTY IN FLOW IMPEDANCE MEASUREMENTS ARISING FROM SHEAR-INDUCED ROTATION OF PARTICLES IN MICROFLUIDIC CHANNELS", The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Groningen, Netherlands, 3-7, October, 2010.

[22] S. Neethirajan and F. Lin, "Covergence - Big Potential: Microfluidics for Food, Agriculture and Biosystems Industries”, XVIIth World Congress of the International Commission of Agricultural Engineering (CIGR), Québec City, Canada, June 13-17, 2010.

 

2009

 

[21] F. Lin, “A Microfluidics-Based Method for Analyzing Leukocyte Migration to Chemoattractant Gradients”, Methods in Enzymology, 2009, Vol. 461, Chapter 15, 333-347.

 

2004-2008

 

[20] Francis Lin and Eugene C. Butcher, “Modeling the Role of Homologous Receptor Desensitization in Cell Gradient Sensing”, Journal of Immunology, 2008, 181(12): 8335-43.

[19] Francis Lin, Fabio Baldessari, Christina Crenguta Gyenge, Tohru Sato, Robert D. Chambers, Juan G. Santiago and Eugene C. Butcher, “Lymphocyte Electrotaxis in vitro and in vivo”, Journal of Immunology, 2008, 181(4): 2465-71. Featured in the "In this issue" section.

[18] Francis Lin, Bong Geun Chung, Wajeeh Saadi, and Noo Li Jeon, “Gradient-Generating Microfluidic Devices for Cell Biology Research”, Chapter 2, Micro- and Nano-Engineering of the Cell Microenvironment: Technologies and Applications, Artech House Publishing Inc, March 2008.

[17] Bong Geun Chung, Amir Manbachi, Wajeeh Saadi, Francis Lin, Noo Li Jeon and Ali Khademhosseini. “A gradient generating microfluidic device for cell biology, J. Visualized Exp. 2007, 7:271.

[16] Wajeeh Saadi, Seog Woo Rhee, Francis Lin, Behrad Vahidi, Bong Geun Chung and Noo Li Jeon, “Generation of Stable Concentration Gradients in 2D and 3D Environments Using a Microfluidic Ladder Chamber”, Biomedical Microdevices, 2007, 9(5):627-35.

[15] Francis Lin and Eugene C. Butcher, “T Cell Chemotaxis in a Simple Microfluidic Device”, Lab on a Chip, 2006, 6: 1462-1469.

[14] Bong Geun Chung, Francis Lin (co-first author) and Noo Li Jeon, “A Microfluidic Multi-Injector for Gradient Generation”, Lab on a Chip, 2006, 6(6):764-8.
Top ten most accessed article in June 2006 .

[13] Wajeeh Saadi, Shur-Jen Wang, Francis Lin, and Noo Li Jeon. “A Parallel-Gradient Microfluidic Chamber for Quantitative Analysis of Breast Cancer Cell Chemotaxis”, Biomedical Microdevices, 2006, 82(2): 109-118.

[12] Francis Lin, Connie Minh-Canh Nguyen*, Shur-Jen Wang, Wajeeh Saadi, Steven P. Gross and Noo Li Jeon, “Neutrophil Migration in Opposing Chemoattractant Gradients Using Microfluidic Chemotaxis Devices”, Annals of Biomedical Engineering, 2005, 33: 473-480.

[11] Wajeeh Saadi, Shur-Jen Wang, Francis Lin, and Noo Li Jeon. “Chemotaxis of Metastatic Breast Cancer Cells in Parallel Gradient Microfluidic Chambers”, NSTI-Nanotech, 2005, 1: 15-18.

[10] Francis Lin, , “Neutrophil Migration in Microfluidic Devices and Actin-based Intracellular Transport”, Ph.D. thesis, University of California, Irvine, 2004.

[9] Francis Lin, Connie Minh-Canh Nguyen, Shur-Jen Wang, Wajeeh Saadi, Steven P. Gross and Noo Li Jeon, “Effective Neutrophil Chemotaxis is Strongly Influenced by Mean IL-8 Concentration”, Biochemical and Biophysical Research Communications, 2004, 319: 576-581.

[8] Francis Lin, Wajeeh Saadi, Seog Woo Rhee, Shur-Jen Wang, Sukant Mittal and Noo Li Jeon, “Generation of Dynamic Temporal and Spatial Concentration Gradients Using Microfluidic Devices”, Lab on a Chip, 2004, 4: 164-167. Selected as a Hot Article.

[7] Shur-Jen Wang, Wajeeh Saadi, Francis Lin, Connie Minh-Canh Nguyen and Noo Li Jeon, “Differential Effect of EGF Gradient Profiles on Breast Cancer Cell Chemotaxis", Experimental Cell Research, 2004, 300: 180-9.

[6] Joseph Snider, Francis Lin, Neda Zahedi, Vladimir Rodionov, Clare C. Yu and Steven P. Gross, “Intracellular Actin-based Transport: How Far You Go Depends on How Often You Switch”, PNAS, 2004, 101: 13204-9.

 

Active Patents

 

[5] Q. Jiang, J.D. Wu, F. Lin, and C.B. Yang, “A paper based microfluidic DON-Chip for rapid and low cost deoxynivaleneol detection”, US Patent, filed on Sept. 26. 2019, Application number: US 62/906441.

 

[4] F. Lin, J.D. Wu, C. Rigatto, P. Komenda, N. Tangri and M. Zhang, “A Passive Mixing Microfluidic Urinary Albumin Chip (UAL-Chip) for Chronic Kidney Disease Assessment”, US Patent, filed on Sept. 24, 2018, Application No: US 62/735 295.

[3]
F. Lin and J.D. Wu, “Method for optimizing microfluidic device prototype”, US Patent, filed on Aug. 8, 2019, Application No: PCT/CA2019/051085.

 

[2] F. Lin and J.D. Wu, “Microfluidic chemotaxis assay”, US Patent, filed on Apr. 8, 2016, Application No: US 62/312,570.

[1] F. Lin and J.D. Wu, “Low-Cost Portable Microfluidic System for Cell Migration Studies”, US Patent Granted on Mar. 26, 2018, Application No: 14/425,139.